Transvaginal colour Doppler ultrasound in predicting response to chemoradiation in patients with carcinoma of the cervix

Authors

  • Mishu Mangla Sanwai ManSingh Medical College
  • Deepak Singla BPS Government Medical College

Keywords:

transvaginal colour Doppler ultrasound, TVCDUS, cervical cancer, resistance index, pulsatality index, RI, PI

Abstract

Background: The objective of the study was to evaluate the potential role of transvaginal colour Doppler ultrasound (TVCDUS) in predicting response to chemoradiotherapy in patients with locally advanced cervical cancer. Method: TVCDUS was used in 56 patients with histologically proven cervical carcinoma (stage IIA–IIIB) before the start of chemoradiation, and after one and three months of therapy. Resistive index (RI) and pulsatality index (PI) were calculated using TVCDUS. Tumour response to chemotherapy was determined. Complete response was when no residual tumour was found, partial response if the tumour volume decreased by more than 50%, and no response when there was no appreciable change in the size of tumour, or the tumour volume decreased to less than 50% of the original volume. Results: A statistically significant increase in RI and PI was demonstrated with TVCDUS following treatment in patients who had a complete and partial response to chemoradiation, compared to those who had no response. Conclusion: TVCDUS is useful in predicting clinical response to concurrent chemoradiation in patients with locally advanced cervical cancer. Thus, it is recommended during the pretreatment evaluation and follow-up.

Author Biographies

  • Mishu Mangla, Sanwai ManSingh Medical College
    MBBS, MS (OBST and GYNAE) Ex Resident Sanwai ManSingh Medical College Jaipur India
  • Deepak Singla, BPS Government Medical College
    MBBS, MD (Anaesthesia) Assistant Professor Department of Anaesthesia BPS Government Medical College Khanpur-Kalan Sonipat Haryana

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Published

2015-05-05

Issue

Vol. 7 No. 2 (2015)

Section

Short Communications

License

South African Journal of Gynaecological Oncology (SAJGO) Copyright is held by South African Society of Gynaecologic Oncology (SASGO). Copyright of the articles is held by the authors. The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC). Material submitted for publication in the SAJGO is accepted provided it has not been published elsewhere. The SAJGO does not hold itself responsible for statements made by the authors. The opinions expressed in this publication are those of the authors. They do no purport to reflect the opinions or views of SASGO or its members.