Gestational choriocarcinoma in a postmenopausal woman: a case report – lessons for the junior clinician

Authors

Keywords:

choriocarcinoma, postmenopausal bleeding, gestational trophoblastic diseases, Beta HCG, neoplasia

Abstract

Choriocarcinoma is a rare form of malignancy originating from epithelial trophoblastic tissue. Unusual and varied presentations of choriocarcinoma present clinicians with a diagnostic challenge. Education is pertinent to ensure a high index of suspicion of the condition to promote a timely diagnosis and better prognosis for patients. This case report discusses an atypical presentation of a 48-year-old postmenopausal woman with gestational choriocarcinoma, with a possible preceding molar pregnancy. It highlights learning points for clinicians regarding gestational trophoblastic diseases, the relevance of persistently high quantitative serum Beta human chorionic gonadotrophin (Beta HCG) values, differential diagnoses for postmenopausal bleeding, co-existent pathologies and choriocarcinoma.

Author Biographies

  • RT West, Mitchell’s Plain District Hospital

    Department of Obstetrics and Gynaecology, Mitchell’s Plain District Hospital, South Africa

  • T Adams, University of Cape Town

    Department of Obstetrics and Gynaecology, Groote Schuur Hospital, University of Cape Town, South Africa

  • N Fakie, University of Cape Town

    Department of Radiation Oncology, Groote Schuur Hospital, University of Cape Town, South Africa

  • W Mkhombe, Mitchell’s Plain District Hospital

    Department of Obstetrics and Gynaecology, Mitchell’s Plain District Hospital, South Africa

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Published

2023-02-08

Issue

Section

Case Studies