HER-2 Testing: ASCO/CAP Guidelines and Beyond - Implications for South Africa

Authors

  • Simon J Nayler

Keywords:

HER-2 Testing, ASCO/CAP Guidelines

Abstract

HER2 status in breast cancer has major signifi cance in terms of prognostication and prediction of response to chemotherapeutic agents, as well as being an absolute indicator for the use of trastuzumab. Recent guidelines for the testing and interpretation for HER2 overexpression have resulted in more accurate and concordant results. Excellent concordance between immunohistochemistry and in situ hybridisation techniques can be achieved if these recommendations and guidelines are followed. The recently developed diagnostic techniques of chromagenic in situ hybridisation (CISH) and brightfi eld dual in situ hybridisation (BDISH) combine the techniques of  immunohistochemistry (IHC) and in situ  hybridisation (ISH) and will revolutionise HER2 testing.

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Published

2010-07-20

Issue

Vol. 2 No. 1 (2010)

Section

Review Articles

License

South African Journal of Gynaecological Oncology (SAJGO) Copyright is held by South African Society of Gynaecologic Oncology (SASGO). Copyright of the articles is held by the authors. The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC). Material submitted for publication in the SAJGO is accepted provided it has not been published elsewhere. The SAJGO does not hold itself responsible for statements made by the authors. The opinions expressed in this publication are those of the authors. They do no purport to reflect the opinions or views of SASGO or its members.