Retrospective analysis of patients with cancer of the cervix attending a radiotherapy outpatient department: experience from a university-based hospital in eastern Uttar Pradesh, India

Authors

  • Moujhuri Nandi Apollo Gleneagles Cancer Hospital
  • Abhijit Mandal Banaras Hindu University
  • Anupam Asthana Banaras Hindu University

Keywords:

cancer of the cervix, retrospective analysis, epidemiology, radiotherapy, chemotherapy, toxicity, response rates

Abstract

Objective: A retrospective analysis of all patients with cancer of the cervix attending a radiotherapy outpatients department in a single unit from January 2005 to December 2006 was carried out to study their epidemiology, stage and status of presentation, compliance with treatment and follow-up, as well as response and complication rates. Design: This was a retrospective study. Setting and subjects: Four hundred and ninety-five consecutively registered patients with cancer of the cervix were included in the study, which was carried out between January 2007 and December 2008. Outcome measures: The epidemiology, stage and status of presentation, compliance with treatment and follow-up, as well as the response and complication rates of the treated patients were the outcome measures. Results: Most of the patients hailed from the various districts of Uttar Pradesh (58%) and Bihar (32%), India. The majority (> 50%) were aged 40-59 years. Stage information was available for 70% of the patients, of which stage 1 comprised 5%, stage 2, 36%; stage 3, 56%; and stage 4, 3%. Squamous cell carcinoma was the most common reported histopathology (~90%). A significant proportion of the women defaulted after registration, or after undergoing investigations (34%). Of the 65% cases planned for treatment, 50% initiated it, but only 35% completed it, according to protocol. Radical radiotherapy was planned for the majority of women (>90%) with or without chemotherapy. Compliance with follow-up was poor (26%). At the time of the analysis, 63% patients had a complete response, 12% residual disease, 16% progressive disease and 7% locoregional recurrence. Recorded late complications were mostly grade I and II bladder and rectal toxicity. Conclusion: The outcome of this study will significantly help us to define region-specific strategies needed for the management of cervical cancer in eastern Uttar Pradesh, India.

Author Biographies

  • Moujhuri Nandi, Apollo Gleneagles Cancer Hospital
    MBBS, MD Junior Consultant Department of Radiation Oncology Apollo Gleneagles Cancer Hospital Kolkata India
  • Abhijit Mandal, Banaras Hindu University
    MSc (Phy), DipRP, PhD Department of Radiotherapy and Radiation Medicine Institute of Medical Sciences Banaras Hindu University Uttar Pradesh India
  • Anupam Asthana, Banaras Hindu University
    MBBS, MD (Radiotherapy) Professor Department of Radiotherapy & Radiation Medicine Institute of Medical Sciences Banaras Hindu University Uttar Pradesh India

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Published

2015-03-13

Issue

Vol. 7 No. 1 (2015)

Section

Original Research

License

South African Journal of Gynaecological Oncology (SAJGO) Copyright is held by South African Society of Gynaecologic Oncology (SASGO). Copyright of the articles is held by the authors. The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC). Material submitted for publication in the SAJGO is accepted provided it has not been published elsewhere. The SAJGO does not hold itself responsible for statements made by the authors. The opinions expressed in this publication are those of the authors. They do no purport to reflect the opinions or views of SASGO or its members.