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Abstract
Lower genital tract gynaecological cancers remain classic examples of diseases which are so-called noncommunicable, but which are caused by infective agents; challenging our desire to classify in order to control. The epidemiology of these cancers follows that of several sexually transmitted infections. Interactions between different infective agents are intriguing, and although often studied, remain difficult to prove and understand. Current evidence demonstrates viruses to be by far the most important infective oncogenes, with other infections acting as co-factors in transmission at most. An intact mucosa in cervical pathogenesis may be critical, as has also been demonstrated in human immunodeficiency virus (HIV) transmission trials.Downloads
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South African Journal of Gynaecological Oncology (SAJGO) Copyright is held by South African Society of Gynaecologic Oncology (SASGO). Copyright of the articles is held by the authors. The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License (CC BY NC). Material submitted for publication in the SAJGO is accepted provided it has not been published elsewhere. The SAJGO does not hold itself responsible for statements made by the authors. The opinions expressed in this publication are those of the authors. They do no purport to reflect the opinions or views of SASGO or its members.