A pilot study of two radiation fractionation regimens in patients with cancer of the cervix, who were HIV positive and not on antiretroviral therapy

  • Alain Marcel Hocepied Steve Biko Academic Hospital
  • Henry Westerink Steve Biko Academic Hospital
  • Roy Lakier Steve Biko Academic Hospital
Keywords: HIV, radiotherapy, locally advanced cervical cancer

Abstract

The Department of Radiation Oncology at the previously named Pretoria Academic Hospital (now the Steve Biko Hospital) undertook a pilot study between 2000 and 2001 of 20 patients who were human immunodeficiency virus-positive with locally advanced cancer of the cervix. At the time of the study, these patients were not on antiretroviral therapy, as per government policy. The patients were randomised into two arms. Six patients underwent a short palliative course of radiotherapy and 13 received a protracted and radical course of radiotherapy. One patient was lost to follow-up. Although the results were not statistically significant, the short course of palliative radiotherapy was adequate in terms of toxicity. As expected, the radical course was associated with a greater and more significant toxicity, because of the suppressed immune status of the participants.

Author Biographies

Alain Marcel Hocepied, Steve Biko Academic Hospital
MD (Brussels), MMed (Rad Onc) Steve Biko Academic Hospital Pretoria
Henry Westerink, Steve Biko Academic Hospital
MBChB, MMed (Rad Onc) Steve Biko Academic Hospital Pretoria
Roy Lakier, Steve Biko Academic Hospital
Bsc (Wits), MBChB, MMed (Rad Onc) Steve Biko Academic Hospital Pretoria
Published
2012-08-20
Section
Original Research