Mitotically active cellular fibroma of the ovary: a rare case and review of literature

  • Rohini Kulkarni HCG Cancer Hospital
  • Rani Bhat HCG Cancer Hospital
  • Vibhawari Dhakharia HCG Cancer Hospital
  • Aparna Gangoli HCG Cancer Hospital
  • Kunal Sharma HCG Cancer Hospita
Keywords: Mitotically active cellular fibroma of ovary, MACF, fibrosarcoma

Abstract

Mitotically active cellular fibroma (MACF) is a category of fibromatous tumours of the ovary described in the WHO classification of tumours of female reproductive organs. The case of a 54-year-old female who presented with lower limb swelling due to deep vein thrombosis (DVT) is reported. On examination, she had a 5 × 8 cm fixed pelvic mass. She underwent optimal cytoreductive surgery. Grossly the tumour, which was found to occupy the left pelvic space, was hard and irregular in shape and was adherent to the surrounding structures. Histopathology revealed collagen-producing spindle cells showing mitotic activity of 6–8/10 HPF with minimal nuclear atypia and Ki 67 labelling index of 10%. A final diagnosis of MACF was made. In view of sparse evidence regarding its management and due to residual tumour (< 1 cm), she received adjuvant radiotherapy. She has remained disease free over a period of two years. (Full text available online at www.medpharm.tandfonline.com/ojgo) South Afr J Gynaecol Oncol 2017; DOI: 10.1080/20742835.2017.1361644

Author Biographies

Rohini Kulkarni, HCG Cancer Hospital
Department of Gynaecological Oncology HCG Cancer Hospital Bengaluru
Rani Bhat, HCG Cancer Hospital
Department of Gynaecological Oncology HCG Cancer Hospital Bengaluru
Vibhawari Dhakharia, HCG Cancer Hospital
Department of Gynaecological Oncology HCG Cancer Hospital Bengaluru
Aparna Gangoli, HCG Cancer Hospital
Department of Pathology HCG Cancer Hospital Bengaluru
Kunal Sharma, HCG Cancer Hospita
Department of Pathology HCG Cancer Hospital Bengaluru
Published
2017-12-04
Section
Case Studies