Immunohistochemistry markers in diagnosing high-grade serous carcinoma of ovary with breast metastasis: a rare case report

  • Thiraviyam Elumalai Jawaharlal Institute of Postgraduate Medical Education
  • Ashutosh Mukherji Jawaharlal Institute of Postgraduate Medical Education
  • Debasis Gochhait Jawaharlal Institute of Postgraduate Medical Education
Keywords: Ovarian cancers, breast mass, metastases to breast, relapse in breast, rare ovarian presentation.

Abstract

Ovarian cancer patients presenting with breast metastasis are a rare phenomenon. Very few cases have been documented so far in the literature and have shown that long-term prognosis of these patients is poor despite intense chemotherapy schedules. This report discusses a case of high-grade serous carcinoma of the ovary with metastases to the right breast and axilla in a 49-year old female as the first case in the authors’ centre in South India. Additional immunohistochemistry markers were checked to confirm the diagnosis. The patient was on the third line of chemotherapy in December 2015. It is strongly emphasised that breast examination should be routine in all cases of ovary malignant tumours. IHC markers may differentiate between second primary versus metastatic secondaries in the breast. Further clinical trials using novel chemotherapy and systematic review of all case reports may help to form uniform consensus guidelines for these rare entities. (Full text available online at www.medpharm.tandfonline.com/ojgo) South Afr J Gynaecol Oncol 2016; DOI: 10.1080/10.1080/20742835.2016.1239355

Author Biographies

Thiraviyam Elumalai, Jawaharlal Institute of Postgraduate Medical Education
Department of Radiotherapy Regional Cancer Centre Jawaharlal Institute of Postgraduate Medical Education
Ashutosh Mukherji, Jawaharlal Institute of Postgraduate Medical Education
Department of Radiotherapy Regional Cancer Centre Jawaharlal Institute of Postgraduate Medical Education
Debasis Gochhait, Jawaharlal Institute of Postgraduate Medical Education
Department of Pathology Jawaharlal Institute of Postgraduate Medical Education
Published
2016-12-06
Section
Research Articles